Tirzepatide injection sites, without the guesswork
Tap where your last shot went and get a simple weekly rotation across the three areas the label lists.
Plan your rotation
Where did your last shot go?
First shot? Choose the spot with your clinician and the Instructions for Use — then come back to plan the rotation.
Which day is shot day?
Pick your last spot and your plan appears here.
Your next eight weeks
A different area every week, alternating sides — so every spot rests for six.
Then the loop starts over. Saved on this device, so your plan is here next week.
What the tirzepatide labels actually say
Tirzepatide is the active ingredient in Mounjaro and Zepbound — a once-weekly shot given subcutaneously, under the skin. MedlinePlus, the NIH’s plain-language drug reference, lists the stomach area, the thigh, and the upper arm. The FDA labels for both brands say the same, with one consistent caveat: the back of the upper arm is a site another person should inject, not one to reach for yourself.
Why rotating matters
The tirzepatide labels ask you to change the injection site with each weekly dose, and to rotate within whichever area you choose. They give the reason plainly — repeatedly injecting one place can lead to pitted or thickened skin and lumps at the site. Cleveland Clinic covers the same ground under the name lipohypertrophy, and its prevention advice is identical: a fresh site every time, about a finger width from the last.
Is there an official rotation order?
None is published. “Rotate” is the requirement; the sequence is left open, which is where the guesswork starts. This planner offers one even loop — three areas, left and right, six spots, one per week — so every spot gets weeks of rest before it comes back. It’s a way to keep track, not medical instruction, and a clinician’s pattern takes precedence over it.
Read the full guide: where to inject a GLP-1 →Planners for other medications
Tirzepatide injection sites, answered
Where do you inject tirzepatide?
MedlinePlus and the Mounjaro and Zepbound labels give the stomach area, the thigh, and the back of the upper arm, for a once-weekly injection under the skin. The upper-arm site is one another person should inject. Which area suits you best is a conversation for your clinician.
Do you have to rotate tirzepatide injection sites?
The labels say to change the injection site with each weekly dose, and to rotate within the area you choose. Rotation is generally recommended to protect the skin you inject into.
What is lipohypertrophy?
A lump of fatty tissue that can form under the skin after repeated injections in one area, as Cleveland Clinic describes it. The tirzepatide labels warn about related skin changes and give rotation as the answer.
Is it the same for Mounjaro and Zepbound?
Yes — both are tirzepatide and name the same three areas, so the rotation doesn’t change between them. There are dedicated planners for each, and Tonic tracks whichever you’re on.
Sources
- Tirzepatide Injection — MedlinePlus Drug Information — NIH MedlinePlus
- Mounjaro (tirzepatide) — FDA Prescribing Information — FDA, label revision 2025
- Lipohypertrophy — Symptoms, Causes, Treatment & Prevention — Cleveland Clinic
On tirzepatide? Tonic logs each shot, remembers your rotation, and suggests the next spot when dose day comes around.
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